Publications et Médias

Vous retrouverez ici toutes les publications, brevets et vidéos qui font partis de la carrière de nos scientifiques.



  • Lavoie, S., Ouellet, M., Fleury, P.Y., Gauthier, C., Legault, J., Pichette, A. Complete 1H and 13C NMR assignments of a series of pergalloylated tannins. Magnetic Resonance in Chemistry, 2016, 54, 168-174.


  • Lavoie, S., Gauthier, C., Mshvildadze, V., Legault, J., Pichette, A. Theoretical Calculations and ROESY NMR for the Diastereochemical Characterization of Cytotoxic Tetraterpenes Isolated from the Oleoresin of Abies balsamea. Journal of Natural Products, 2015, 78(12), 2896-2907.
  • St-Gelais, A. Legault, J. Mshvildadze, V., Pichette, A. Dirchromones: Cytotoxic organic sulfur compounds isolated from Dirca palustris L. (Thymelaeaceae), Journal of Natural Products, 2015, 78(8), 1904-1909.
  • Simard, F., Gauthier, C., Chiasson, E., Lavoie, S., Mshvildadze, V. Legault, J., Pichette, A. Antibacterial Balsacones J-M, hydroxycinnamoylated dihydrochalcones from Populus balsamifera buds. Journal of Natural Products, 2015, 78(5), 1147-1153.
  • Getia, M., Mshvildadze, M., Dekanosidze, G., Pichette, A. Quantification of a crude extract from Hedera colchica. International Journal of Pharmaceutical Sciences and Research, 2015, 6(9), 3836-3840.
  • Oueslati, S., Ellili, A., Legault, J., Pichette, A., Ksouri, R., Lachaal, M., Karray-Bouraoui, N. Phenolic content, antioxidant and anti-inflammatory activities of Tunisian Diplotaxis simplex (Brassicaceae). Natural Product Research, 2015, 29(12), 1189-1191.
  • St-Gelais, A., Caron, L., Collin, G., Marceau, H.E., Pichette, A. Aromas from Quebec. III. Composition of the Essential Oil and Hydrolate of the Roots of Anthriscus sylvestris from Saguenay. Journal of Essential Oil Research, 2015, 27(5), 373-379.
  • Hock, V., Chouinard, G., Lucas, E., Cormier, D., Leskey, T., Wright, S., Zhang, A., Pichette, A. Behavioral Responses of Plum Curculio (Coleoptera: Curculionidae) to Different Enantiomer Concentrations and Blends of the Synthetic Agregation Pheromone Grandisoic Acid. Journal of Economic Entomology, 2015, 108(2), 549-558.


  • Sylla, B., Gauthier, C., Fleury, P.Y., Legault, J., Lavoie, S., Mshvildadze, V., Muzashvili, T., Kemertelidze, E., Pichette, A. Stereoselective synthesis of hellecaucaside A: a new disaccharide nucleoside from Helleborus caucasicus. Carbohydrate Research, 2014, 398, 80-89.
  • Simard, F., Lavoie, S., Legault, J., Pichette, A. Balsacones D-I, antibacterial hydroxycinnamylated dihydrochalcones from buds of Populus balsamifera L. Phytochemistry, 2014, 100, 141-149.
  • Medini, F., Legault, J., Pichette, A., Abdelly, C., Ksouri, R. Antiviral efficacy of Limonium densiflorum against HSV-1 and influenza viruses. South African Journal of Botany, 2014, 92, 65-72.
  • Oueslati, S., Ksouri, R., Pichette, A., Lavoie, S., Girard-Lalancette, K., Mshvildadze, V., Abdelly, C., Legault, J. A new flavonol glycoside from the medicinal halophyte Suaeda fruticosa. Natural Product Research, 2014, 28 (13), 960-966.
  • Piochon, M., Legault, J., Sylvestre, M., Pichette, A. Populus balsamifera buds essential oil: Chemical composition and cytotoxic activity. Natural Product Communications, 2014, 9(2), 257-260.
  • Nadaraia, N. S., Kakhabrishvili, M.L., Onashvili, E.O., Barbakadze, N.N., Getia, M.Z., Pichette, A.Sikharulidze, M.I., Makhmudov, U. S. Synthesis of several 5-α-androstano[17,16-d] pyrazolines from tigogenin. Chemistry of Natural Compounds, 2014, 50 (6) 1024-1028.
  • Alaniya, M.D., Sutiashvili, M.G., Shalashvili, K.G., Skhirtladze, A.V., Mshvildadze, V., Pichette, A. Iridoid glycosides from roots of Verbascum laxum. Chemistry of Natural Compounds, 2014, 50 (5) 842-845.
  • Hock, V., Chouinard, G., Lucas, E., Cormier, D., Leskey, T., Wright, S., Zhang, A., Pichette, A. Establishing abiotic and biotic factors for reliable pheromone production from male plum curculios (Conotrachelus nenuphar Herbst), The Canadian Entomologist, 2014, 146(5), 528-545.


  • Lavoie, S., Legault, J., Simard, F., Chiasson, E., Pichette, A. New antibacterial dihydrochalcone derivatives from buds of Populus balsamifera, Tetrahedron Letters, 2013, 54, 1631-1633.
  • Lavoie, S., Gauthier, C., Legault, J., Mercier, S., Mshvildadze, V., Pichette, A. Lanostane- and cycloartane-type triterpenoids from Abies balsamea oleoresin. Beilstein Journal of Organic Chemistry, 2013, 9, 1333-1339.
  • Legault, J., Côté, P.-A., Ouellet, S., Simard, S., Pichette, A. Iso-caryophyllene cytotoxicity induced by lipid peroxidation and membrane permeabilization in L-929 cells. Journal of Pharmacy and Pharmaceutical Sciences, 2013, 3, 25-31.
  • Legault, J., Girard-Lalancette, K., Dufour, D., Pichette, A. Antioxidant Potential of Bark Extracts from Boreal Forest Conifers. Antioxidants, 2013, 2, 77-89.
  • Caron, L., Deslauriers, A., Mshvildadze, V., Pichette, A. Volatile compounds in the foliage of balsam fir (Abies balsamea) analyzed by static headspace gas chromatography (HS-GC). Microchemical Journal, 2013, 110, 587-590.
  • Saha, S., Kocaefe, D., Boluk, Y., Pichette, A. Surface degradation of CeCO2 stabilized acrylic polyurethane coated thermally treated jack pine during accelerated weathering. Applied Surface Science, 2013, 276, 86-94.
  • Saha, S., Kocaefe, D., Krause, C., Boluk, Y., Pichette, A. Enhancing exterior durability of heat-treated jack pine by photostabilisation by acrylic polyurethane coating using bark extract. Part 2: Wetting characteristics and fluorescence microscopy analysis. Progress in Organic Coatings, 2013, 76, 504-512.
  • Saha, S., Kocaefe, D., Boluk, Y., Mshvildadze, V., Legault, J., Pichette, A. Boreal forest conifer extracts: Potential natural additives for acrylic polyurethane coatings for the protection of heat-treated jack pine. Journal of Coatings Technology and Research, 2013, 10 (1), 109-122.
  • Sutiashvili, M. G., Alaniya, M. D., Mshvildadze, V. D., Skhirtladze, A. V., Pichette, A., Lavoie, S. Flavonoid and cycloartane glycosides from seeds of Koelreuteria paniculata. Chemistry of Natural Compounds, 2013, 49 (2), 395-397.


  • Lavoie, S. Legault, J., Gauthier, C., Mshvildadze, V., Mercier, S., Pichette, A. Abibalsamins A and B, two novel tetraterpenoids from Abies balsamea oleoresin. Organic Letters, 2012, 14 (6), 1504-1507.
  • Huang, X., Kocaefe, D., Boluk, Y., Kocaefe, Y., Pichette, A. Effect of surface preparation on the wettability of heat-treated jack pine wood surface by different liquids. European Journal of Wood and Wood Products, 2012, 70(5), 711-717.
  • Georges, P., Legault, J., Lavoie, S., Grenon, C., Pichette, A. Diterpenoids from the buds of Pinus banksiana Lamb. Molecules, 2012, 17(8), 9716-9727.
  • Gauthier, C., Thibeault, D., Legault, J., Bouchard, J., Gagné, L., Pichette, A. Synthesis and Cytotoxicity of lupane-type triterpenoid glyceryl esters. Bioorganic and Medicinal Chemistry Letters, 2012, 22(14), 4735-4739.
  • Oueslati, S., Ksouri, R., Falleh, H., Pichette, A., Abdelly, C., Legault, J. Phenolic content, antioxidant, anti-inflammatory and anticancer activities of the edible halophyte Sueda fruticosa Forssk. Food Chemistry, 2012, 132(2), 943-947.
  • Huang, X., Kocaefe, D., Kocaefe, Y., Boluk, Y., Pichette, A. Study of the degradation behavior of heat-treated jack pine (Pinus banksiana) under artificial sunlight irradiation. Polymer Degradation and Stability, 2012, 97(7), 1197-1214.
  • Bourgou, S., Pichette A, Marzouk B, Legault J. Antioxidant, anti-inflammatory, anticancer and antibacterial activities of extracts from Nigella sativa (black cumin) plant parts. Journal of Food Biochemistry, 2012, 36(5), 539-546.
  • Huang, X., Kocaefe, D., Kocaefe, Y., Boluk, Y., Pichette, A. Changes in wettability of heat-treated wood due to artificial weathering. Wood Science and Technology, 2012, 46(6), 1215-1237.
  • Bourgou S, Pichette A, Lavoie S, Marzouk B, Legault J. Terpenoids isolated from Tunisian Nigella sativa L. with antioxidant and inhibiting of NO activities. Flavour and Fragrance Journal, 2012, 27, 69-74.
  • Garneau, F.-X., Collin, G., Gagnon, H., Pichette, A. Chemical Composition of the Hydrosol and the Essential Oil of Three Different Species of the Pinaceae Family : Picea glauca (Moench) Voss., Picea mariana (Mill.) B.S.P. and Abies balsamea (L.) Mill. Journal of Essential Oil Bearing Plants, 2012, 15(2), 227-236.
  • Huang, X., Kocaefe, D., Kocaefe, Y, Boluk, Y., Pichette, A. A spectrocolorimetric and chemical study on color modification of heat-treated wood during artificial weathering. Applied Surface Science, 2012, 258, 5360-5369.


  • Bellila, A., Tremblay, C., Pichette, A., Marzouk, B., Mshvildadze, V., Lavoie, S., Legault, J. Cytotoxic activity of withanolides isolated from Tunisian Datura metel L. Phytochemistry, 2011, 72, 2031-2036.
  • Legault J., Perron T., Girard-Lalancette K., Longtin A., Sirois P., Pichette A. Antioxidant and Anti-inflammatory Activities of Quercetin 7-O-β-10- glucopyranoside from the Leaves of Brasenia schreberi. Journal of Medicinal Food, 2011, 14, 1127-1134.
  • Getia, M.Z., Gabelaya, M.A., Mshvildadze, V.D., Pichette, A., Lavoie, S., Dekanosidze, G.E. A new triterpene glycoside from fruit of Phytolacca Americana. Chemistry of Natural Compounds, 2011, 47(5), 764-766.
  • Legault, J., Larouche, P.-L., Coté, I., Bouchard, L., Pichette, A., Robinson, B.H., Morin, C. Low-concentration methylene blue maintains energy production and strongly improves survival of Leigh Syndrome French Canadian skin fibroblasts, Journal of Pharmacy and Pharmaceutical Sciences, 2011, 14, 438-449.
  • Gauthier, C.; Legault, J.; Piochon, M.; Pichette, A. Advances in the synthesis and pharmacological activity of lupane-type triterpenoids. Phytochemistry Reviews, 2011, 10, 521-544.
  • Jonville, MC., Kodja, H., Strasberg, D., Pichette, A., Ollivier, E., Frédérich, M., Angenot, L., Legault, J. Antiplasodial, anti-inflammatory and cytotoxic activities of various plant extracts from the Mascarene Archipelago. Journal of Ethnopharmacology, 2011, 136(3), 525-531.
  • Saha, S., Kocaefe, D., Boluk, Y., Pichette, A. Enhancing Exterior Durability of Jack Pine by Photo-Stabilization of Acrylic Polyurethane Coating using Bark Extract: Part 1- Effect of UV on Color Change and ATR-FTIR Analysis. Progress in Organic Coating, 2011, 70 (4) 376-382.
  • Saha, S., Kocaefe, D., Sarkar, D. K., Boluk, Y. Pichette, A. Effect of TiO2-containing Nano-coatings on the Color Protection of Heat-treated Jack pine. Journal of Coating Technology and Research, 2011, 8 (2) 183-190.
  • Kavtaradze, N.S., Alaniya, M.D., Mshvildadze, V.D. Skhirtladze, A.V., Lavoie, S., Pichette, A. Flavonoids from Astragalus microcephalus. Chemistry of Natural Compounds, 2011, 46(6), 971-973.
  • Alaniya, M.D., Kavtaradze, N.S., Lavoie, S., Pichette, A., Mshvildadze,V.D., Apakidze, Z.Z. Chemical constituents of the aerial part of Astragalus bungeanus, Chemistry of Natural Compounds, 2011, 46(6), 1001-1003.


  • Bozhadze, A., Mshvildadze, V.D., Legault, J., Pichette, A., Vachnadze, V., Bakuridze, A. Study on cytotoxic activity of some isoquinoline alkaloids and extracts of Chelidonium majus L. growing in Georgia, Allergology and Immunology, 2010, 11 (2), 172-174.
  • Pichette, A., Eftekhari, A., Georges, P., Lavoie, S., Mshvildadze, V., Legault, J. Cytotoxic phenolic compounds in leaf-buds of Populus tremuloides, Canadian Journal of Chemistry, 2010, 88(2), 104-110.
  • Ngoumfo, R.M., Jouda, J.-B., Mouafo, F.T., Komguem, J., Mbazoa, C.D., Shiao, T.C., Choudhary, M.I., Laatsch, H., Legault, J., Pichette, A. and Roy, R. In vitro cytotoxic activity of isolated acridones alkaloids from Zanthoxylum leprieurii Guill. et Perr, Bioorganic and Medicinal Chemistry, 2010, 18(10), 3601-3605.
  • Legault, J., Girard-Lalancette, K., Grenon, C., Dussault, C., Pichette, A. Antioxidant activity, inhibition of NO overproduction and in vitro antiproliferative effect of maple sap and syrup from Acer saccharum. Journal of Medicinal Food, 2010, 13 (2), 460-468.
  • Thibeault, D., Legault, J., Gauthier, C., Lavoie, S., Bouchard, J., Pichette, A. Acid-Catalyzed E-Ring Expansion and Isomerization of 3-Acetylbetulin: Synthesis of Cytotoxic Anhydrobetulin Saponins, Synthetic Communications, 2010, 40(2), 213-221.
  • Bourgou, S., Pichette, A. Marzouk, B., Legault, J. Bioactivities of black cumin essential oil and its main terpenes from Tunisia, South African Journal of Botany, 2010, 76(2), 210-216.
  • Collin, G., Garneau, F.-X., Gagnon, H., Lavoie, S., Pichette, A. Analysis of Cymenes in Essential Oils. The case of Lepechinia meyeni (Walp.) Epling, Journal of Essential Oil Research, 2010, 22, 310-314.
  • Piochon, M., Legault, J., Pichette, A. Chemical composition of the essential oil from Solidago puberula Nutt. growing wild in the north of Quebec, Journal of Essential Oil Research, 2010, 22, 228-229.
  • Bélanger, A. Collin, G., Garneau, F.-X., Gagnon, H., Pichette, A. Aromas from Quebec. II. Composition of the essential oil of the rhizomes and roots of Asarum canadense L., Journal of Essential Oil Research, 2010, 22, 164-169.

Plusieurs autres articles ont été publié avant 2010


  • Legault, J., Pichette, A. Côté, I., Lavoie, S. Use of plant extracts against herpes simplex virus. Demande de brevet PCT/CA2014/050693, 37 pp.
  • Pichette, A., Legault, J., Simard, F. Dihydrochalcone derivatives and their use as antibiotic agents. Demande préliminaire de brevet No. 61/694,480, 43 pp. 29 août 2012. Cette demande de brevet revendique les droits d’utilisation de plusieurs composés de type dihydrochalcone comme agents antibiotiques.
  • Legault, J., Pichette, A. Compositions for prevention or treatment of anorexia-cachexia syndrome and uses thereof. WO2008144880, 4 décembre 2008. Cette demande brevet revendique les droits d’utilisation de sesquiterpènes pour la prévention ou le traitement de la cachexie.
  • Pichette, A., Legault, J., Gauthier, C. Bidesmosidic Betulin and Betulinic Acid Saponins and Uses Thereof as Antitumor Agents. WO2010028487, 18 mars 2010. Cette demande de brevet provisoire américaine revendique l’utilisation de saponines bidesmosidiques à génines acide bétulinique et bétulinol contenant diverses sections sucres aux positions C-3 et C-28 à titre d’agent anticancéreux.
  • Pichette, A., Legault, J., Gauthier, C. Triterpene Derivatives and Uses Thereof as Antitumor or Anti-Inflammatory Agents. CA2586614 & US20080167254, 10 juillet 2008. Cette demande de brevet déposée aux États-Unis et au Canada vise à obtenir les droits d’utilisation de saponines triterpéniques de type lupane (lupéol, bétulinol, acide bétulinique et bétulinate de méthyle) et germanicane (allobétulinol et 28-oxoallobétulinol) et de leur différentes compositions pharmaceutiques à titre d’agents anticancéreux et/ou anti-inflammatoires.
  • Pichette, A., Legault, J., Lavoie, S. Sesquiterpenes formulations, kits and methods of uses thereof. WO2008144942, 4 décembre 2008. Cette demande de brevet revendique les droits d’utilisation de formulations novatrices contenant différents sesquiterpènes hydrophobes qui potentialisent l’efficacité d’agents anticancéreux déjà utilisés en clinique.
  • Legault, J., Pichette, A. Potentiator of antitumoral agents in the treatments of cancer. WO03020371, 13 mars 2003. Ce brevet revendique les droits d’utilisation de composés terpéniques pour potentialiser (augmenter l’efficacité) l’activité antitumorale d’agents anticancéreux déjà utilisés en clinique.
  • Pichette, A., Legault, J. Antitumor methods and compositions comprising sesquiterpene derivatives. WO02078719, 30 septembre 2004. Ce brevet revendique les droits d’utilisation de sesquiterpènes d’origine naturelle comme agents anticancéreux.
  • Gaudet, D. Pichette, A. Process for Preparing Natural Product Derivatives from Plant in a Single Step. WO0026174, 11 mai 2000. Ce brevet décrit une approche novatrice d’extraction-transformation servant à extraire et à transformer simultanément le bétulinol en dérivés de plus grande valeur commerciale.